Search results for "Two-bottle choice paradigm"

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Acetaldehyde self-administration by a two-bottle choice paradigm: Consequences on emotional reactivity, spatial learning, and memory

2015

Abstract Acetaldehyde, the first alcohol metabolite, is responsible for many pharmacological effects that are not clearly distinguishable from those exerted by its parent compound. It alters motor performance, induces reinforced learning and motivated behavior, and produces different reactions according to the route of administration and the relative accumulation in the brain or in the periphery. The effective activity of oral acetaldehyde represents an unresolved field of inquiry that deserves further investigation. Thus, this study explores the acquisition and maintenance of acetaldehyde drinking behavior in adult male rats, employing a two-bottle choice paradigm for water and acetaldehyd…

MaleHealth (social science)MetaboliteEmotionsWistarSpatial LearningMorris water navigation taskSelf AdministrationAlcoholAcetaldehydeMotor ActivityToxicologyChoice BehaviorBiochemistryDevelopmental psychologyBehavioral Neurosciencechemistry.chemical_compoundMemoryAnimalsSpatial learning and memoryRats WistarMaze LearningMedicine (all)Cognitive flexibilityAcetaldehydeBrainAnxiety-like behaviorCognitionGeneral MedicineRatsAcetaldehyde in the brain; Anxiety-like behavior; Emotional reactivity; Spatial learning and memory; Two-bottle choice paradigm; Acetaldehyde; Animals; Brain; Choice Behavior; Emotions; Male; Maze Learning; Memory; Motor Activity; Rats; Rats Wistar; Self Administration; Spatial LearningTwo-bottle choice paradigmNeurologychemistryAnxiogenicEmotional reactivitySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoAcetaldehyde in the brainSettore BIO/14 - FarmacologiaSelf-administrationPsychologyNeuroscienceAlcohol
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